FUNGI
Molds
Dematiaceous
Alternaria
Bipolaris
Curvularia
Exophiala
Hyaline
Zygomycetes
Mucor
Absidia
Cunninghamella
Rhizomucor
Rhizopus
Aspergillus
Fusarium
Scedosporium
Yeasts
Candida
C. albicans
C. glabrata
C. parapsilosis
C. tropicalis
C. krusei
C. lusitaniae
C. dubliniensis
C. auris
Cryptococcus
C. neoformans
C. gattii
Dimorphic
Blastomyces
Coccidioides
Histoplasma
Sporothrix
Paracoccidioides
Dermatophytes
Trichophyton
Microsporum
Epidermophyton
Strongly recommended
Moderately recommended
Marginally recommended
Recommended against
Treatment Guidelines for Fungal Infections
Condition First-line First-line alternative Second-line Treatments to avoid Salvage treatments
Fusariosis Voriconazole, or voriconazole plus L-AmB, or voriconazole plus ABLC L-AmB, or ABLC Isavuconazole, or posaconazole D-AmB Posaconazole
Lomentosporosis Voriconazole plus terbinafine Voriconazole Isavuconazole, or posaconazole L-AmB Voriconazole
Scedosporiosis Voriconazole Voriconazole in combination with L-AmB, ABLC, echinocandins, or terbinafine Isavuconazole, or posaconazole, or itraconazole L-AmB Voriconazole, echinocandins, or posaconazole
Phaeohyphomycosis: localised infection Voriconazole L-AmB with or without echinocandins, or triazole Isavuconazole D-AmB Isavuconazole, or posaconazole, or voriconazole
Phaeohyphomycosis: cutaneous or subcutaneous infection Itraconazole or voriconazole L-AmB with or without echinocandins, or triazole Isavuconazole D-AmB Isavuconazole, or posaconazole, or voriconazole
Phaeohyphomycosis: disseminated infection Posaconazole, or voriconazole plus echinocandins, or voriconazole plus terbinafine L-AmB with or without echinocandins, or triazole Isavuconazole D-AmB Isavuconazole, or posaconazole, or voriconazole
Phaeohyphomycosis: Exserohilum rostratum Voriconazole with or without L-AmB - L-AmB plus triazoles other than voriconazole D-AmB -
Rasamsonia spp Caspofungin, or micafungin Caspofungin plus L-AmB or posaconazole, or micafungin plus L-AmB or posaconazole - Azole monotherapy -
Schizophyllum commune L-AmB; stepdown to posaconazole - Voriconazole - -
Schizophyllum spp other than S commune and other basidiomycetes L-AmB with or without inhaled L-AmB, or L-AmB with or without voriconazole - Voriconazole Echinocandins L-AmB, or voriconazole
Scopulariopsis spp Isavuconazole, or voriconazole L-AmB with or without voriconazole - - Posaconazole with or without micafungin with or without terbinafine
Penicillium spp: disseminated infection L-AmB with or without other antifungals - - - Voriconazole
Penicillium spp: lung infection Posaconazole - - - Voriconazole
Non-marneffei Talaromyces spp L-AmB - - - Voriconazole, or echinocandin plus terbinafine
Paecilomyces spp L-AmB - - - Itraconazole, or posaconazole
Purpureocillium spp Voriconazole - Itraconazole or L-AmB or posaconazole - Itraconazole, or L-AmB, or posaconazole
Purpureocillium spp: cutaneous or subcutaneous infection Voriconazole plus terbinafine - Itraconazole or L-AmB or posaconazole - Itraconazole, or L-AmB, or posaconazole